Vasodilator drugs and heart-related outcomes in systemic sclerosis: an exploratory analysis.

ABSTRACT:

Background and aims

Systemic sclerosis (SSc) is an autoimmune connective disease characterised by excessive extracellular matrix deposition and widespread skin and internal organ fibrosis including various cardiac manifestations. Heart involvement is one of the leading causes of death among patients with SSc. In this study, we aimed to assess the effect of various vasodilator treatments.

Methods

We used data from a national multicentric prospective study using the French SSc national database. We estimated the average treatment effect (ATE) of sildenafil, bosentan, angiotensin-converting enzyme (ACE) inhibitors and iloprost on diastolic dysfunction, altered ejection fraction <50% and pulmonary arterial hypertension (PAH) using a causal method, namely the longitudinal targete

SUBMITTER: Guedon AF 

PROVIDER: S-EPMC11629012 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature