METTL3-VISTA axis-based combination immunotherapy for APC truncation colorectal cancer.

ABSTRACT:

Objective

Although immune checkpoint blockade (ICB) therapy represents a bright spot in antitumor immunotherapy, its clinical benefits in colorectal cancer (CRC) are limited. Therefore, a new target for mediating CRC immunosuppression is urgently needed. Adenomatous polyposis coli (APC) mutations have been reported as early-stage characteristic events in CRC, but the role of truncated APC in the CRC immune microenvironment remains unclear and its clinical significance has yet to be explored.

Design

Adenocarcinoma formation in the colon of the APC^Min/+ mouse model, which displays features associated with the translation of truncated APC proteins, was induced by azoxymethane/dextran sodium sulfate. Multiplexed immunohistochemical consecutive staining on single slide

SUBMITTER: Wu L 

PROVIDER: S-EPMC11629097 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature