Sex-related differences in amyotrophic lateral sclerosis: A 2-[¹⁸F]FDG-PET study.

ABSTRACT:

Purpose

We investigated sex-related brain metabolic differences in Amyotrophic Lateral Sclerosis (ALS) and healthy controls (HC).

Methods

We collected two equal-sized groups of male (m-ALS) and female ALS (f-ALS) patients (n = 130 each), who underwent 2-[¹⁸F]FDG-PET at diagnosis, matched for site of onset, cognitive status and King's stage. We included 168 age-matched healthy controls, half female (f-HC) and half male (m-HC). We compared brain metabolism of males and females separately for ALS and HC, including age as covariate. A differential network analysis was performed to evaluate brain connectivity.

Results

M-ALS showed relative hypometabolism of bilateral medial frontal, parietal and occipital cortices, and left temporal cortex, compared to f-ALS. In

SUBMITTER: Canosa A 

PROVIDER: S-EPMC11629101 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature