West African Genetic Ancestry and Breast Cancer Outcomes Among Black Women.

ABSTRACT:

Importance

Young Black women bear a disproportionate burden of breast cancer deaths compared with White women, yet they remain underrepresented in genomic studies.

Objective

To evaluate the association of biological factors, including West African genetic ancestry, and nonbiological factors with disease-free survival (DFS) among young Black women with breast cancer.

Design, setting, and participants

This observational cohort study included Black women diagnosed with invasive breast cancer between January 1, 2005, and December 31, 2016. Participants diagnosed with breast cancer at age 50 years or younger were recruited through the Florida and Tennessee state cancer registries. The final analysis was completed between June and September 2024.

Exposure

West Africa

SUBMITTER: Reid S 

PROVIDER: S-EPMC11629124 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature