Weekly Cisplatin Cycles and Outcomes for Chemoradiation in Head and Neck Cancer.

ABSTRACT:

Importance

National Comprehensive Cancer Network guidelines recommend weekly cisplatin as an alternative concurrent systemic therapy for definitive chemoradiation in patients with head and neck cancer. However, the impact of different levels of adherence to weekly cisplatin on outcomes stratified by human papillomavirus p16 status remains unclear.

Objective

To evaluate the association between the number of weekly cisplatin cycles and outcomes.

Design, setting, and participants

This retrospective, observational, single-institution cohort study at The Ohio State Comprehensive Cancer Center included patients with a diagnosis of nonmetastatic head and neck cancer between December 1, 2011, and March 30, 2020, who received chemoradiation. Data analysis was performed between

SUBMITTER: Ma SJ 

PROVIDER: S-EPMC11629129 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature