Synthesis, characterization, biological activities, and computational studies of pyrazolyl-thiazole derivatives of thiophene.

ABSTRACT: This study reports the synthesis, characterization, and biological evaluation of a series of pyrazolyl-thiazole derivatives of thiophene. Seven compounds were synthesized and characterized using NMR spectroscopy and mass spectrometry. The antimicrobial activities of these derivatives were evaluated against various bacterial (Escherichia coli, Bacillus subtilis, Bacillus megaterium, Staphylococcus aureus) and fungal strains (Aspergillus niger, Aspergillus oryzae, Rhizopus, Candida albicans), demonstrating significant inhibition zones and low minimum inhibitory concentrations (MIC). In addition, the compounds exhibited notable antioxidant activities in DPPH and hydroxyl radical scavenging assays. Computational studies, including density

SUBMITTER: Bhagwat SK 

PROVIDER: S-EPMC11629146 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature