DEC1 deficiency protects against bone loss induced by ovariectomy through inhibiting inflammation.

ABSTRACT: Previous studies have shown that differentiated embryo-chondrocyte expressed gene 1 (DEC1) promotes osteoblast osteogenesis. To investigate the role of DEC1 in postmenopausal osteoporosis (PMOP), we utilized the two types (DEC1 ^+/+, DEC1 ^-/-) mice to establish an ovariectomy (OVX) model and found that the bone loss in DEC1 ^-/- OVX mice were much less than that in DEC1 ^+/+ OVX mice. The expression levels of RUNX2 and OSX significantly increased in DEC1 ^-/- OVX mice compared with those in DEC1 ^+/+ OVX mice. Whereas, NFATc1, c-Fos, CTSK and RANKL/OPG significantly decreased in DEC1 ^-/- OVX mice compared with those in DEC1 ^+/+ OVX mice. Likewise, DEC1 deficiency suppressed IL-6 and IL-1β. Further study show

SUBMITTER: Lin L 

PROVIDER: S-EPMC11629160 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature