Myeloid clonal hematopoiesis of indeterminate potential in patients with chronic lymphocytic leukemia.

ABSTRACT:

Abstract

Clonal hematopoiesis of indeterminate potential (CHIP) in patients with chronic lymphocytic leukemia (CLL) has not been extensively characterized. The objective of this study was to describe the prevalence of myeloid CHIP (M-CHIP) in patients with CLL, and to determine its association with time to first treatment (TTFT) and overall survival (OS). We retrospectively analyzed data from patients participating in a prospective CLL database at the Dana-Farber Cancer Institute who had standard-of-care targeted 95-gene next-generation sequencing (NGS) performed. A schema was devised to classify mutations as M-CHIP related. M-CHIP was analyzed as a binary (present/absent) and categorical (≥2 vs 1 vs 0 mutations) predictor. We included 966 patients (median age at time of NGS, 65 ye

SUBMITTER: Vijenthira A 

PROVIDER: S-EPMC11629178 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature