Prevalence of celiac disease-specific antibodies and their association with clinical status and environmental factors.

ABSTRACT:

Background and aims

Celiac disease (CeD) affects 1-2% of the world's population. The aim of this study was to relate the incidence of CeD-related serological markers to symptoms, pathologies, and environmental exposure to wheat flour, given the number of flour mills present in the region.

Materials & methods

Serum samples were collected from 537 inhabitants from a rural city. Levels of anti-transglutaminase (a-tTg), anti-gliadin, anti-DGP antibodies and total IgA levels were measured. Volunteers completed a questionnaire covering environmental factors, demographics, pregnancies, other diseases, symptoms, and CeD diagnosis. Geo-referencing of volunteers' homes and mills in the city was performed, and correlations between the different parameters assessed were analysed.

Res

SUBMITTER: de Diego GA 

PROVIDER: S-EPMC11629211 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature