Protective effect of xylosma congesta extract on renal injury in hyperuricemic rats.

ABSTRACT:

Background

The purpose of this study was to investigate the protective effect of xylosma congesta extract on kidney injury in hyperuricemic rats.

Methods

The rats were fed yeast extract and intraperitoneal injections of potassium oxonate for 3 weeks to establish the hyperuricemia model. And then the rats were treated with allopurinol and different doses of oak extract. The contents of uric acid in urine and serum, creatinine, and urea nitrogen in serum were detected by biochemical methods. TUNEL was used to detect cell apoptosis in renal tissue. The protein expression of TLR4 and NF- kappa B (NF-κB) p65 and the proportion of CD68 and CD206 positive cells in renal tissue were detected by pathological method.

Results

The xylosma congesta group showed decreased renal tub

SUBMITTER: He J 

PROVIDER: S-EPMC11629226 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature