Sex differences in the prevalence and survival of pulmonary hypertension in obstructive hypertrophic cardiomyopathy following septal myectomy.

ABSTRACT:

Background

Pulmonary hypertension (PH) and female have been linked to a worse survival in patients with obstructive hypertrophic cardiomyopathy (oHCM). However, female patients with PH exhibited a better prognosis than males. Herein, we investigated sex differences in the prevalence and survival of pH in oHCM following septal myectomy.

Methods

We consecutively enrolled 1491 patients diagnosed with oHCM. PH was defined as a pulmonary artery systolic pressure (PASP) > 36 mm Hg.

Results

Females were older, more likely to experience chest pain and NYHA class III/IV symptoms, and had a higher prevalence of PH (37.6 % vs. 19.9 %, p < 0.001) than males. Multivariable analysis showed that female was an independent risk for PH (OR 2.3, 95 % CI: 1.70-3.11, p < 0.001) though the

SUBMITTER: Nie C 

PROVIDER: S-EPMC11629235 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature