Comparison of MIBG uptake in the major salivary glands between Lewy body disease and progressive supranuclear palsy.

ABSTRACT:

Introduction

Cardiac sympathetic denervation is specific to Lewy body disease (LBD). In Parkinson's disease (PD), sympathetic denervation in the major salivary glands (parotid glands [PG] and submandibular glands [SMG]) has been demonstrated by ¹²³I-metaiodobenzylguanidine (MIBG) scintigraphy. We compared sympathetic denervation in the MSG between PD, dementia with Lewy bodies (DLB), and progressive supranuclear palsy (PSP).

Methods

We recruited 81 patients with PD, 12 with DLB, 13 with PSP and 25 with control subjects. We evaluated MIBG uptake in the major salivary glands and heart using a quantitative semi-automatic method. We compared MIBG uptake between PD, DLB, and PSP patients and controls, and we evaluated disease sensitivity and specificity. We compared ol

SUBMITTER: Ebina J 

PROVIDER: S-EPMC11629250 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature