Refractory phenotype of <i>Aspergillus</i>-sensitized asthma with bronchiectasis and allergic bronchopulmonary aspergillosis.

ABSTRACT:

Background

Sensitization to Aspergillus, mucus plugs, and bacterial colonization may coexist and relate to a refractory phenotype during follow-up in asthma with bronchiectasis and allergic bronchopulmonary aspergillosis (ABPA).

Objective

This study aimed to clarify the features of Aspergillus-sensitized refractory asthma with bronchiectasis and determine the refractory phenotype in this population and ABPA.

Methods

This study included cases of the oldest available Aspergillus fumigatus-specific IgE data and chest computed tomography images from a nationwide survey of refractory asthma with bronchiectasis. The characteristics of the A fumigatus-IgE positive (Af sIgE⁺) group were investigated and compared with its nonsensit

SUBMITTER: Nomura N 

PROVIDER: S-EPMC11629325 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature