Erythropoietin to Treat Spinal Cord Injury: Evaluation of Different Doses and Magnitudes of Trauma in Rats.

ABSTRACT:

Study design

Experimental spinal cord lesion study.

Objectives

To evaluate the effects of erythropoietin at different doses on neural regeneration in rats undergoing spinal cord injury.

Methods

Anesthetized Wistar rats were submitted to standardized spinal cord injury and randomized into eight groups, receiving different magnitudes of trauma and single or repeated doses of intraperitoneal erythropoietin (500 or 5000 IU/kg of body weight). We evaluated motor function using BBB scores and sensorimotor behavior by observing the rats walking on a horizontal ladder (at 2, 4, and 6 weeks) and performed histological analysis of the spinal cord after euthanasia. We compared the scores between groups using analysis of variance (ANOVA) and Bonferroni multiple comparisons.

Re

SUBMITTER: Barros AGC 

PROVIDER: S-EPMC11629366 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature