Unraveling Cecal Alterations in <i>Clostridioides difficile</i> Colonized Mice through Comprehensive Metabolic Profiling.

ABSTRACT: The disruption of gut microbiota caused by antibiotics favors the intestinal colonization of Clostridioides difficile - a Gram-positive, spore-forming anaerobic bacterium that causes potentially fatal gastrointestinal infections. In an endeavor to elucidate the complexities of the gut-brain axis in the context of Clostridium difficile infection (CDI), a murine model has been used to investigate the potential effects of antibiotic administration and subsequent colonization by C. difficile, as well as the impact of three different 10-day treatments (metronidazole, probiotics, and fecal microbiota transplantation), on the cecal metabolome for the first time. This follows our previous research which highlighted the metabolic effect of CDI and these treatments in the brain

SUBMITTER: Deda O 

PROVIDER: S-EPMC11629376 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature