Cognitive Impairment Mechanisms in High-Altitude Exposure: Proteomic and Metabolomic Insights.

ABSTRACT: High-altitude exposure can adversely affect neurocognitive functions; however, the underlying mechanisms remain elusive. Why and how does high-altitude exposure impair neurocognitive functions, particularly sleep? This study seeks to identify the molecular markers and mechanisms involved, with the goal of forming prevention and mitigation strategies for altitude sickness. Using serum proteomics and metabolomics, we analyzed blood samples from 23 Han Chinese plain dwellers before and after six months of high-altitude work in Tibet. The correlation analysis revealed biomarkers associated with cognitive alterations. Six months of high-altitude exposure significantly compromised cognitive function, notably, sleep quality. The key biomarkers implicated include SEPTIN5, PCBP1, STIM1, UBE2L3/I/N,

SUBMITTER: Zhao Q 

PROVIDER: S-EPMC11629389 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature