Spatial and temporal dynamics of HDACs class IIa following mild traumatic brain injury in adult rats.

ABSTRACT: The fundamental role of epigenetic regulatory mechanisms involved in neuroplasticity and adaptive responses to traumatic brain injury (TBI) is gaining increased recognition. TBI-induced neurodegeneration is associated with several changes in the expression-activity of various epigenetic regulatory enzymes, including histone deacetylases (HDACs). In this study, PET/CT with 6-([¹⁸F]trifluoroacetamido)-1- hexanoicanilide ([¹⁸F]TFAHA) to image spatial and temporal dynamics of HDACs class IIa expression-activity in brains of adult rats subjected to a weight drop model of diffuse, non-penetrating, mild traumatic brain injury (mTBI). The mTBI model was validated by histopathological and immunohistochemical analyses of brain tissue sections for localization and magnitude of e

SUBMITTER: Kamal SR 

PROVIDER: S-EPMC11629393 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature