The systemic impact of non-surgical treatment of peri-implantitis with or without adjunctive systemic metronidazole: Secondary analysis of a randomized clinical trial.

ABSTRACT:

Objectives

The aim of this study was to evaluate the systemic effect of non-surgical peri-implantitis treatment (NSPIT) with or without the administration of systemic metronidazole.

Methods

In this secondary analysis from a previously published clinical trial (NCT03564301), peri-implantitis patients were randomized into two groups: test, receiving NSPIT plus 500 mg of oral systemic metronidazole three times a day for 7 days (n = 10); and control group, receiving NSPIT plus placebo (n = 11). Serum samples were obtained at baseline, 3 and 6 months after therapy to determine levels of inflammatory biomarkers, lipid fractions and complete blood counts.

Results

Both treatment modalities produced improvements in clinical and radiographic parameters. After 6 months from NSPI

SUBMITTER: Linares A 

PROVIDER: S-EPMC11629454 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature