Clinical characteristics and early identification of augmented renal clearance in PICU patients with severe sepsis associated with MRSA infection.

ABSTRACT:

Objectives

To investigate the epidemiological characteristics of Augmented Renal Clearance (ARC) in severe sepsis children with MRSA infection and find risk factors to establish a model predicting ARC onset in PICU.

Design

Retrospective study, in which ARC was defined by estimated glomerular filtration rate (eGFR) measured by the modified Schwartz formula above 130 ml/min/1.73 m². Univariable and multivariable logistic regression analyses were performed to find the predictor for ARC. Multi-strategy modeling was used to form an early prediction model for ARC, which was evaluated by the area under the ROC curve (AUC), accuracy (ACC) and other indicators.

Setting

One China PICU.

Patients

Severe sepsis children with MRSA infection admitted to PICU from M

SUBMITTER: Wang H 

PROVIDER: S-EPMC11629473 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature