Loss of <i>Cdkn1a</i> protects against MASLD alone or with alcohol intake by preserving lipid homeostasis.

ABSTRACT:

Background & aims

Expression of P21, encoded by the CDKN1A gene, has been associated with fibrosis progression in steatotic liver disease (SLD); however, the underlying mechanisms remain unknown. In the present study, we investigated the function of CDKN1A in SLD.

Methods

CDKN1A expression levels were evaluated in different patient cohorts with SLD, fibrosis, and advanced chronic liver disease (ACLD). Cdkn1a ^-/- and Cdkn1a ^+/+ mice were fed with either a Western diet (WD), a Lieber-DeCarli (LdC) diet plus multiple EtOH (ethanol) binges, or a DuAL diet (metabolic dysfunction-associated fatty liver disease and alcohol-related liver). Primary hepatocytes were isolated and functional assays performed.

Results

A significant

SUBMITTER: Lamas-Paz A 

PROVIDER: S-EPMC11629569 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature