Establishment of CD1b-restricted immunity to lipid antigens in the pulmonary response to <i>Mycobacterium tuberculosis</i> infection.

ABSTRACT: CD1 is an antigen-presenting glycoprotein homologous to MHC I; however, CD1 proteins present lipid rather than peptide antigens. CD1 proteins are well established to present lipid antigens of Mycobacterium tuberculosis (Mtb) to T cells, but understanding the role of CD1-restricted immunity in vivo in response to Mtb infection has been limited by the availability of animal models naturally expressing the CD1 proteins implicated in human response: CD1a, CD1b, and CD1c. Guinea pigs, in contrast to other rodent models, express four CD1b orthologs, and here we utilize the guinea pig to establish the kinetics of gene and protein expression of CD1b orthologs, as well as the Mtb lipid-antigen and CD1b-restricted immune response at the tissue level over the course of Mtb infection. Ou

SUBMITTER: Harris MC 

PROVIDER: S-EPMC11629625 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature