A conserved interaction between the effector Sca4 and host clathrin suggests additional contributions for Sca4 during rickettsial infection.

ABSTRACT: Intracellular bacterial pathogens deploy secreted effector proteins that manipulate diverse host machinery and pathways to promote infection. Although many effectors carry out a single function or interaction, there are a growing number of secreted effectors capable of interacting with multiple host factors. However, few effectors secreted by arthropod-borne obligate intracellular Rickettsia species have been linked to multiple host targets. Here, we investigated the conserved rickettsial secreted effector Sca4, which was previously shown to interact with host vinculin in donor cells to promote cell-to-cell spread in the model Rickettsia species R. parkeri. We discovered that Sca4 also binds the host cell protein clathrin heavy chain (CHC, CLTC) via a conserved

SUBMITTER: Vondrak CJ 

PROVIDER: S-EPMC11629629 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature