The causal relationship between the human gut microbiota and pyogenic arthritis: a Mendelian randomization study.

ABSTRACT:

Background

Recent studies have indicated the role of the gut microbiota in the progression of osteoarticular diseases, however, the causal relationship between the gut microbiota and pyogenic arthritis remains unclear. There is also a lack of theoretical basis for the application of the gut microbiota in the treatment of pyogenic arthritis.

Methods

In our study, we utilized the largest genome-wide association study (GWAS) data from the MiBioGen Consortium involving 13,400 participants and extracted summary statistical data of the microbiota metabolic pathways of 7,738 participants of European descent from the Dutch Microbiome Project (DMP) The data of pyogenic arthritis were derived from the FinnGen R10 database, including 1,086 patients and 147,221 controls. We employed the

SUBMITTER: Bai B 

PROVIDER: S-EPMC11629706 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature