Dynamic modelling of signalling pathways when ordinary differential equations are not feasible.

ABSTRACT:

Motivation

Mathematical modelling plays a crucial role in understanding inter- and intracellular signalling processes. Currently, ordinary differential equations (ODEs) are the predominant approach in systems biology for modelling such pathways. While ODE models offer mechanistic interpretability, they also suffer from limitations, including the need to consider all relevant compounds, resulting in large models difficult to handle numerically and requiring extensive data.

Results

In previous work, we introduced the retarded transient function (RTF) as an alternative method for modelling temporal responses of signalling pathways. Here, we extend the RTF approach to integrate concentration or dose-dependencies into the modelling of dynamics. With this advancement, RTF modellin

SUBMITTER: Rachel T 

PROVIDER: S-EPMC11629707 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature