Leucine-rich repeat proteins of <i>Leptospira interrogans</i> that interact to host glycosaminoglycans and integrins.

ABSTRACT: Pathogenic spirochaetes of the genus Leptospira are the etiological agents of leptospirosis, a zoonotic infection worldwide. The disease is considered an emerging and re-emerging threat due to global warming, followed by heavy rainfall and flooding when outbreaks of leptospirosis occur. Adhesion to host tissues is mediated by surface/extracellular proteins expressed by pathogens during infection. Leucine-rich repeat (LRR) domain-containing proteins seem to be important for the virulence of pathogenic Leptospira and their role has been recently examined. Here, we report the characterization of two LRR-proteins encoded by LIC11051 and LIC11505. They present 7 and 17 LRR motifs, respectively. LIC11051 was found mainly in the P1 subclade, whereas LIC11505 was identified with high

SUBMITTER: Foltran BB 

PROVIDER: S-EPMC11629876 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature