A low-toxicity uranyl-selective-binding linear pentapeptide sequence as a potential uranium decorporation agent.

ABSTRACT: Searching for highly selective, efficient, and low-toxicity chelating agents is central to resolving uranium contamination in vivo. Peptides composed of amino acids exhibit very low toxicity for accumulation in the human body and have been proven effective in chelating actinides within the human body. Herein, we report a rationally designed short phosphorylated peptide sequence PP-B, which exhibits high affinity and selectivity for uranyl compared to other trace elements present in the body (such as Na⁺, K⁺, Ca²⁺, Co²⁺, Fe²⁺, Fe³⁺, Mg²⁺, Mn²⁺, Zn²⁺). The association constant for the peptide-uranyl complex is calculated to be 7.3 ×10⁵ M^-1. The result of DFT calcula

SUBMITTER: Tan X 

PROVIDER: S-EPMC11629939 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature