Effectiveness of non-invasive brain stimulation on depressive symptoms targeting prefrontal cortex in functional magnetic resonance imaging studies: a combined systematic review and meta-analysis.

ABSTRACT: The prefrontal cortex (PFC) is a critical non-invasive brain stimulation (NIBS) target for treating depression. However, the alterations of brain activations post-intervention remain inconsistent and the clinical moderators that could improve symptomatic effectiveness are unclear. The study aim was to systematically review the effectiveness of NIBS on depressive symptoms targeting PFC in functional magnetic resonance imaging (fMRI) studies. In our study, we delivered a combined activation likelihood estimation (ALE) meta-analysis and meta-regression. Until November 2020, three databases (PubMed, Web of Science, EMBASE) were searched and 14 studies with a total sample size of 584 were included in the ALE meta-analysis; after NIBS, four clusters in left cerebrum revealed significant activati

SUBMITTER: Xiao Y 

PROVIDER: S-EPMC11629992 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature