SUrvey of renal Biopsy registry database and Anticancer dRUg therapy in Japan (SUBARU-J study).

ABSTRACT:

Background

Kidney complications associated with anticancer drug therapy have greatly increased recently. We aimed to investigate the real-world clinical outcomes of anticancer drug therapy-associated renal complications in Japan using the national kidney biopsy database, Japan Renal Biopsy Registry (J-RBR).

Methods

From 2018 to 2021, 449 cases from 49 facilities identified as 'drug-induced' histopathology in the J-RBR were screened, of which a total of 135 were confirmed as anticancer drug-related cases and included in the analysis. Overall survival rates were estimated using the Kaplan-Meier method and compared by logrank test. The Cox regression model was used to evaluate the association between variables and deaths.

Results

The most common primary sites of malignan

SUBMITTER: Kuwabara T 

PROVIDER: S-EPMC11630032 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature