Anhedonia is associated with a specific depression profile and poor antidepressant response.

ABSTRACT:

Background

Anhedonic features within major depressive disorder (MDD) have been associated with worse course and outcome and may predict nonresponse to treatment. However, a detailed clinical profile of anhedonia in MDD is still lacking.

Materials and methods

One thousand two hundred ninety-four patients with MDD were selected from the cross-sectional European multicenter Group for the Study of Resistant Depression study. Anhedonia was assessed through the Montgomery-Åsberg Depression Rating Scale anhedonia item "inability to feel." Clinical and demographic features were then analyzed.

Results

The presence of anhedonia related to a distinct demographical (living alone) and clinical profile (thyroid diseases, diabetes, suicide risk, high number of previous depressive ep

SUBMITTER: Luca A 

PROVIDER: S-EPMC11630035 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature