Multiome-wide Association Studies: Novel Approaches for Understanding Diseases.

ABSTRACT: The rapid development of multiome (transcriptome, proteome, cistrome, imaging, and regulome)-wide association study methods have opened new avenues for biologists to understand the susceptibility genes underlying complex diseases. Thorough comparisons of these methods are essential for selecting the most appropriate tool for a given research objective. This review provides a detailed categorization and summary of the statistical models, use cases, and advantages of recent multiome-wide association studies. In addition, to illustrate gene-disease association studies based on transcriptome-wide association study (TWAS), we collected 478 disease entries across 22 categories from 235 manually reviewed publications. Our analysis reveals that mental disorders are the most frequently studied dise

SUBMITTER: Shao M 

PROVIDER: S-EPMC11630051 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature