Maternal periconception hyperglycemia, preconception diabetes, and risk of major congenital malformations in offspring.

ABSTRACT:

Study question

What are the roles of maternal preconception diabetes and related periconceptional hyperglycemia on the risk of major congenital malformations (MCMs) in offspring?

Summary answer

Maternal periconceptional glycated hemoglobin (HbA1c) levels over 5.6% were associated with an increased risk of congenital heart defects (CHD) in the offspring, and maternal preconception diabetes was associated with an increased risk of CHD, including when HbA1c levels were within euglycemic ranges.

What is known already

Maternal preconception diabetes has been linked with MCMs in the offspring. However, evidence concerning associations with specific periconception serum measures of hyperglycemia, and susceptibility of different organ systems, is inconsistent. Moreover, limit

SUBMITTER: Rotem RS 

PROVIDER: S-EPMC11630054 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature