Vascular and inflammatory biomarkers of cardiovascular events in non-steroidal anti-inflammatory drug users.

ABSTRACT:

Aims

The Standard care vs. Celecoxib Outcome Trial (SCOT) found similar risk of cardiovascular events with traditional non-steroidal anti-inflammatory drugs (NSAIDs) and the cyclooxygenase-2-selective drug celecoxib. While pre-clinical work has suggested roles for vascular and renal dysfunction in NSAID cardiovascular toxicity, our understanding of these mechanisms remains incomplete. A post hoc analysis of the SCOT cohort was performed to identify clinical risk factors and circulating biomarkers of cardiovascular events in NSAID users.

Methods and results

Within SCOT (7295 NSAID users with osteoarthritis or rheumatoid arthritis), clinical risk factors associated with cardiovascular events were identified using least absolute shrinkage and selection operator regressio

SUBMITTER: Vaja R 

PROVIDER: S-EPMC11630077 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature