Clinical and economic burden of suspected thrombotic thrombocytopenic purpura in US hospitals.

ABSTRACT:

Purpose

Severe ADAMTS13 deficiency (activity <10%) is the diagnostic threshold for thrombotic thrombocytopenic purpura (TTP) and is associated with various clinical symptoms, abnormal laboratory results, and long-term complications.

Methods

This retrospective, noninterventional cohort study used the Premier Healthcare Database to identify patients with ADAMTS13 activity of <10% in US hospitals from January 1, 2016, through March 31, 2020. The objective was to describe patient characteristics, laboratory results, comorbidities (as measured by the Elixhauser comorbidity index), symptoms, length of stay, treatment patterns, mortality, inpatient costs, and readmission rates (summarized descriptively). Inpatient costs were calculated as total cost to the hospital.

Results

SUBMITTER: Xing S 

PROVIDER: S-EPMC11630316 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature