Familial risk of sinus node dysfunction indicating pacemaker implantation: a nationwide cohort study.

ABSTRACT:

Aims

We aimed to investigate the risk of sinus node dysfunction (SND) indicating cardiac pacing and mortality in first-degree relatives to patients with a pacemaker implanted on this indication and assess the effect of onset-age on disease risk.

Methods and results

In this nationwide register-based study, we used the Danish Civil Registration Registry to establish family structures and merged data with the Danish National Patient Registry and the Danish Pacemaker and ICD Registry containing information on all pacemakers implanted due to SND in Denmark. We followed 6 027 090 individuals born after 1954 in the period between 1982 and 2022 (180 775 041 person-years) among whom 2.477 pacemakers were implanted due to SND. The adjusted rate ratio (RR) of pacemaker-treated SND was

SUBMITTER: Christiansen MK 

PROVIDER: S-EPMC11630507 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature