Defective autophagy of pericytes enhances radiation-induced senescence promoting radiation brain injury.

ABSTRACT:

Background

Radiation-induced brain injury (RBI) represents a major challenge for cancer patients undergoing cranial radiotherapy. However, the molecular mechanisms and therapeutic strategies of RBI remain inconclusive. With the continuous exploration of the mechanisms of RBI, an increasing number of studies have implicated cerebrovascular dysfunction as a key factor in RBI-related cognitive impairment. As pericytes are a component of the neurovascular unit, there is still a lack of understanding in current research about the specific role and function of pericytes in RBI.

Methods

We constructed a mouse model of RBI-associated cognitive dysfunction in vivo and an in vitro radiation-induced pericyte model to explore the effects of senescent pericytes on the blood-brain barrier

SUBMITTER: Luo N 

PROVIDER: S-EPMC11630511 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature