Clearance of archived integrase strand transfer inhibitors resistance mutations in people with virologically suppressed HIV infection.

ABSTRACT:

Introduction

We assessed the kinetics of the clearance of integrase strand transfer inhibitors resistance mutations (INSTIs-RMs) and associated factors from people living with HIV (PWH) displaying suppressed viral replication after virological failure (VF) on an INSTI regimen.

Patients and methods

We included PWH with HIV-RNA viral loads ≤20 copies/mL for at least 5 years in whom INSTIs-RM had been identified at least once in a prior RNA resistance genotyping test. HIV DNAs were sequenced by Sanger sequencing (SS) and ultra-deep sequencing (UDS; detection threshold: 5%) every year over the preceding 5 years.

Results

We included 39 PWH in the study. Most (95%) had experienced VF on a raltegravir-containing regimen. The past INSTIs-RMs were not detected in the periphera

SUBMITTER: Abdi B 

PROVIDER: S-EPMC11630525 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature