A comparative analysis of IDH-mutant glioma in pediatric, young adult, and older adult patients.

ABSTRACT:

Background

The frequency and significance of IDH mutations in glioma across age groups are incompletely understood. We performed a multi-center retrospective age-stratified comparison of patients with IDH-mutant gliomas to identify age-specific differences in clinico-genomic features, treatments, and outcomes.

Methods

Clinical, histologic, and sequencing data from patients with IDH-mutant, grades 2-4 gliomas, were collected from collaborating institutions between 2013 and 2019. Patients were categorized as pediatric (<19 years), young adult (YA; 19-39 years), or older adult (≥40 years). Clinical presentation, treatment, histologic, and molecular features were compared across age categories using Fisher's exact test or analysis-of-variance. Cox proportional-hazards regression

SUBMITTER: Lim-Fat MJ 

PROVIDER: S-EPMC11630535 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature