Integrin mechanosensing relies on a pivot-clip mechanism to reinforce cell adhesion.

ABSTRACT: Cells intricately sense mechanical forces from their surroundings, driving biophysical and biochemical activities. This mechanosensing phenomenon occurs at the cell-matrix interface, where mechanical forces resulting from cellular motion, such as migration or matrix stretching, are exchanged through surface receptors, primarily integrins, and their corresponding matrix ligands. A pivotal player in this interaction is the α₅β₁ integrin and fibronectin (FN) bond, known for its role in establishing cell adhesion sites for migration. However, upregulation of the α₅β₁-FN bond is associated with uncontrolled cell metastasis. This bond operates through catch bond dynamics, wherein the bond lifetime paradoxically increases with greater force. The mechani

SUBMITTER: Montes AR 

PROVIDER: S-EPMC11630637 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature