LBFextract: Unveiling transcription factor dynamics from liquid biopsy data.

ABSTRACT:

Motivation

The analysis of circulating cell-free DNA (cfDNA) holds immense promise as a non-invasive diagnostic tool across various human conditions. However, extracting biological insights from cfDNA fragments entails navigating complex and diverse bioinformatics methods, encompassing not only DNA sequence variation, but also epigenetic characteristics like nucleosome footprints, fragment length, and methylation patterns.

Results

We introduce Liquid Biopsy Feature extract (LBFextract), a comprehensive package designed to streamline feature extraction from cfDNA sequencing data, with the aim of enhancing the reproducibility and comparability of liquid biopsy studies. LBFextract facilitates the integration of preprocessing and postprocessing steps through alignment fragment t

SUBMITTER: Lazzeri I 

PROVIDER: S-EPMC11630664 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature