Molecular characteristics of advanced colorectal cancer and multi-hit PIK3CA mutations.

ABSTRACT:

Introduction

Approximately 20% of patients living with colorectal cancer (CRC) have activating mutations in their tumors in the PIK3CA oncogene. Two or more activating mutations (multi-hit) for the PIK3CA allele increase PI3K⍺ signaling compared to single-point mutations, resulting in exceptional response to PI3K⍺ inhibition. We aimed to identify the prevalence of PIK3CA multi-hit mutations in metastatic CRC to identify patients who may benefit from PI3K inhibitors.

Methods

The Foundation Medicine database (Boston, MA, USA) was analyzed for patients with CRC who underwent genomic profiling on tumor DNA isolated during routine clinical care from 2013 to 2021. Molecular and clinical variables were abstracted for patients with PIK3CA mutations.

Results

We identified 49 0

SUBMITTER: Yasin F 

PROVIDER: S-EPMC11630746 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature