BRCA1/2 mutations and outcomes among Middle Eastern patients with early-onset breast cancer in Oman.

ABSTRACT:

Background

High prevalence of early-onset breast cancer (EOBC) has been reported in Middle Eastern populations. For example, in Oman more than 50% of patients with breast cancer (BC) are under age 45 at diagnosis. Causes for this high incidence are unknown. Germline BRCA gene mutations have been associated with EOBC, however, prevalence of these mutations and how they relate to EOBC in Oman has not been assessed.

Patients and methods

Clinical data were collected for patients with BC treated at Royal Hospital, Oman between 2010 and 2022. Germline BRCA1/2 gene mutations were identified using sequencing and MLPA. Correlation and Kaplan-Meier survival analyses were performed to test relationships among clinico-pathological features, gene mutations, and outcomes.

Results

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SUBMITTER: Al Amri WS 

PROVIDER: S-EPMC11630774 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature