SLAM/SAP signaling regulates discrete γδ T cell developmental checkpoints and shapes the innate-like γδ TCR repertoire.

ABSTRACT: During thymic development, most γδ T cells acquire innate-like characteristics that are critical for their function in tumor surveillance, infectious disease, and tissue repair. The mechanisms, however, that regulate γδ T cell developmental programming remain unclear. Recently, we demonstrated that the SLAM/SAP signaling pathway regulates the development and function of multiple innate-like γδ T cell subsets. Here, we used a single-cell proteogenomics approach to identify SAP-dependent developmental checkpoints and to define the SAP-dependent γδ TCR repertoire in mice. SAP deficiency resulted in both a significant loss of an immature Gzma⁺Blk⁺Etv5⁺Tox2⁺ γδT17 precursor population and a significant increase in Cd4⁺Cd8

SUBMITTER: Mistri SK 

PROVIDER: S-EPMC11630817 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature