Efficient genome monomer higher-order structure annotation and identification using the GRMhor algorithm.

ABSTRACT:

Motivation

Tandem monomeric units, integral components of eukaryotic genomes, form higher-order repeat (HOR) structures that play crucial roles in maintaining chromosome integrity and regulating gene expression and protein abundance. Given their significant influence on processes such as evolution, chromosome segregation, and disease, developing a sensitive and automated tool for identifying HORs across diverse genomic sequences is essential.

Results

In this study, we applied the GRMhor (Global Repeat Map hor) algorithm to analyse the centromeric region of chromosome 20 in three individual human genomes, as well as in the centromeric regions of three higher primates. In all three human genomes, we identified six distinct HOR arrays, which revealed significantly greater diffe

SUBMITTER: Gluncic M 

PROVIDER: S-EPMC11630843 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature