Low feed intake at weaning reduces intestinal glutathione levels and promotes cysteine oxidation to taurine in pigs.

ABSTRACT: Weaning stress in pigs is associated with low feed intake and poor nutrient utilization. Cysteine is a sulfur amino acid with key roles in pig production, but how cysteine metabolism and requirements are affected by weaning stress should be better defined. The objective of this study was to determine the collective impact of weaning and feed restriction on tissue cysteine metabolism. Pigs were weaned at 21-d age without access to feed (W; 6.90 ± 0.81 kg; n = 9; reflecting acute nutritional stress) or were not weaned and remained with the sow (nonweaned [NW]; 6.81 ± 0.65 kg; n = 8). At euthanasia (23-d age), blood, bile, liver, jejunum, and ileum tissues were collected. Plasma, bile, and tissue amino acid and amino thiol concentrations were analyzed by HPLC. The activity of glutamate cystei

SUBMITTER: Gachman AM 

PROVIDER: S-EPMC11630854 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature