Clinical Significance of Hyponatremia in Tuberculous Meningitis: A Prospective Cohort in Indonesia.

ABSTRACT:

Background

Hyponatremia is common in tuberculous meningitis (TBM), but its impact on disease severity and outcomes is unclear.

Methods

In a cohort of 864 adult patients with TBM in Indonesia, we assessed the prevalence and prognostic significance of hyponatremia, classified as moderate (120-130 mEq/L) or severe (<120 mEq/L). Patients received standard antituberculous therapy and corticosteroids and were followed for 1-year mortality.

Results

Hyponatremia occured in 86.8% of patients, with 26% classified as severe. Severe hyponatremia associated with male, younger age, a lower Glasgow Coma Scale (GCS), and markers of more severe disease (P < .05). One-year mortality was 46.5% and associated with older age, HIV infection, lower GCS, markers of neurologic severity

SUBMITTER: Dian S 

PROVIDER: S-EPMC11630896 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature