The therapeutic effects of Paeoniae Radix Rubra on chronic hepatitis through network pharmacology and molecular docking.

ABSTRACT:

Backgrounds

Chronic hepatitis (CH) refers to liver inflammation lasting at least 6 months caused by various factors, significantly impacting patients' daily lives. Paeoniae Radix Rubra (CS) is a classic blood-activating and stasis-dissolving herb known for its protective effects on the liver. This research seeks to investigate the underlying mechanisms by which CS treat CH, employing network pharmacology and molecular docking.

Methods

The active constituents of CS for CH treatment were identified through the TCMSP database. Targets associated with CH were gathered from GeneCards, the Therapeutic Target Database, and OMIM databases. The intersecting genes between these targets and the components of CS were considered potential therapeutic targets. Protein-protein interaction

SUBMITTER: Yu C 

PROVIDER: S-EPMC11630941 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature