Causal association between cardiovascular risk factors and common skin diseases: A multivariate Mendelian randomization study.

ABSTRACT: Cardiovascular diseases and dermatological conditions are prevalent health issues worldwide. Previous studies have suggested that risk factors for cardiovascular diseases may be associated with the development of dermatological conditions. However, the causal association between these factors remain unclear. This study utilized data from genome-wide association studies and applied Mendelian randomization (MR) to explore the potential causal association between cardiovascular risk factors and common dermatological conditions. Genetic variants significantly associated with low-density lipoprotein cholesterol (LDL-C), serum uric acid, blood glucose, and hypertension were selected as instrumental variables. We employed inverse variance weighted, MR Egger, and weighted mode methods for analysis

SUBMITTER: Peng S 

PROVIDER: S-EPMC11630946 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature