Causality between gut microbiota, immune cells, and breast cancer: Mendelian randomization analysis.

ABSTRACT: The association between gut microbiota (GM) and breast cancer (BC) has been studied. Nevertheless, the causal relationship between them and the potential mediating factors have not been clearly defined. Therefore, in this study, Mendelian randomization analysis (MR) was employed to explore the causal relationship between 473 GM and BC, as well as the mediating effect of potential immune cells. In this investigation, we availed ourselves of the publicly accessible summary statistics from the genome-wide association study to undertake two-sample and reverse Mendelian randomization analyses on GM and BC, with the intention of clarifying the causal association between GM and BC. Subsequently, through the application of the two-step Mendelian randomization analysis, it was revealed that the rel

SUBMITTER: Lv R 

PROVIDER: S-EPMC11630993 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature