Exploring the relationship between gut microbiota, immune characteristics, and female genital tract polyps using genetic evidence.

ABSTRACT: The study investigates the causal relationship between gut microbes and female genital tract polyps, exploring the potential mediating role of immune cells via Mendelian randomization (MR) analysis. Our MR study was designed following the STROBE-MR guidelines. We combined data from a large-scale GWAS meta-analysis, including 731 immune profiles and female genital tract polyps, with gut microbiology data sourced from the MiBioGen consortium. Univariate Mendelian randomization was employed to identify gut microbes and immune profiles significantly associated with female genital tract polyps causally. A 2-step MR analysis was utilized to investigate the potential mediating role of immune cells. Furthermore, we utilized the multivariable MR approach based on Bayesian model averaging (MR-BMA) t

SUBMITTER: Jia R 

PROVIDER: S-EPMC11630997 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature