Construction of a prognostic model based on cuproptosis-related genes and exploration of the value of DLAT and DLST in the metastasis for non-small cell lung cancer.

ABSTRACT:

Background

To reveal the clinical value of cuproptosis-related genes on prognosis and metastasis in non-small cell lung cancer.

Methods

Gene expression profiles and clinical information of non-small cell lung cancer were downloaded from The Cancer Genome Atlas and Gene Expression Omnibus databases. The data were grouped into training set, internal testing set, and external testing set. A risk prognostic model was constructed by Lasso-Cox regression analysis. Hub genes were identified and evaluated using immunohistochemistry and the transwell migration assay in 50 clinical patients.

Results

A total of 17/19 cuproptosis-related genes were differentially expressed in tumors, 8 were significantly associated with prognosis, and 4 were markedly associated with metastasis. A

SUBMITTER: Ma H 

PROVIDER: S-EPMC11631004 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature